Biocanina Pest Control Spot-on solution for large dogs weighing Plus 25 kg Permetrix 3 pipettes

a. Dosage and route of administration

For external use only (spot-on use). Apply to uninjured Skin only.

The minimum recommended dose is : 10 mg imidacloprid per kg body weight and 50 mg permethrin per kg body weight.

Apply to the Skin according to the animal's body weight as follows:

For dogs weighing Plus 40 kg, use the appropriate combination of pipettes.

To ensure correct dosing, the animal's weight should be determined as accurately as possible.

To reduce re-infestation by the emergence of new fleas, it is recommended to treat all dogs in the household. Other pets living in the same household should also be treated with an appropriate product.

In order to reduce parasite pressure in the environment, it is recommended that an appropriate treatment of the environment against adult fleas and their developmental stages be used as a supplement.

Depending on ectoparasitic pressure, it may be necessary to repeat the treatment. The interval between 2 treatments should be 4 weeks. However, in the event of intense and/or prolonged exposure to water, the duration of efficiency may be reduced. In this case, a minimum interval of one week should be observed between applications.

To protect a dog throughout the sandfly season, the treatment must be applied continuously throughout this period.

Transient cosmetic changes may be observed at the application sites (i.e. flaking of the skin, white deposits and stuck-on hairs).

b. Method of administration

Remove a pipette from the pack. Hold the pipette applicator in an upright position. Squeeze the narrow end of the pipette to ensure that all the contents are in the main body of the pipette, rotate and remove the cap. Place the cap, upside down, on the pipette. Press and twist the cap to puncture the pipette, then remove the cap from the pipette.

For dogs weighing 10 kg or less:

With the dog in an upright position, spread the hair between the shoulder blades until the Skin is visible. Place the tip of the pipette on the skin and press firmly several times to empty the contents directly onto the skin.

For dogs weighing Plus 10 kg:

With the dog in an upright position, apply the entire contents of the pipette evenly to four points on the animal's back, from the shoulders to the base of the tail. At each application point, spread the hair until the animal's Skin is visible. Place the tip of the pipette on the skin and press gently to deposit some of the solution on the skin. Do not apply an excessive amount of solution to one of the application points, as this could cause the solution to run down the dog's sides.

c. Contraindications

In the absence of available data, do not use in puppies under 7 weeks of age or weighing less than 10 kg.

Do not use in the event of hypersensitivity to the active substances or to one of the excipients.

Do not use in cats (see "Special precautions for use").
d. Warnings specific to each target species

The attachment of a tick or the bite of mosquitoes or sandflies remains possible. Consequently, the transmission of infectious diseases by these parasites cannot be totally excluded under unfavourable conditions.

Since the product has a repellent effect (anti-gorging) against Aedes aegypti mosquitoes 7 days after treatment, it is preferable to apply the product a week before animals are likely to be exposed to these mosquitoes.

The product remains effective against fleas if the animal is wet. After weekly immersion in water for one minute, the duration of insecticidal efficiency against fleas was not reduced. However, intense and prolonged exposure to water should be avoided. In the event of repeated or prolonged exposure to water, the duration of efficiency may be reduced. In these cases, the treatment should not be repeated more than once a week. If a dog requires shampooing, this should be carried out before applying the product or at least 2 weeks after application, to optimise the product's efficiency.

The efficiency of this product against ticks and the repellent activity of this product after bathing or shampooing has not been studied.

Immediate protection against sandfly bites has not been documented. Dogs treated to reduce the risk of infection with Leishmania infantum transmitted by sandflies P. perniciosus should be kept in a protected environment for the first 24 hours after the initial application of treatment.